Vaccine Case Studies
Launching the First Advanced Market Commitment (AMC)
Situation
Advance Market Commitments (AMCs) are a new mechanism for creating an economically
attractive low-income country market for vaccine suppliers. The objective is to
accelerate the availability of vaccines to these regions of the world and thereby
save the lives of millions of children annually.
For the World Bank and Global Alliance for Vaccines & Immunization (GAVI), Applied
Strategies led an effort to model and analyze the financial and risk implications
of AMC to determine AMC investment level and AMC vaccine price. We achieved buy-in
to the model design and analysis results from a community of diverse stakeholders,
including the G8 Finance Ministers, World Bank, GAVI, Center for Global Development,
multinational and emerging vaccine suppliers, government finance ministries, and
six vaccine-focused public-private partnerships.
Our work was instrumental in convincing government donors to raise $1.5 billion
to support a pilot AMC for pneumococcal vaccines.
Contribution
- Provided an industry best practices framework to understand the
financial implications and risks of the AMC to suppliers, donors, and countries
- Developed a software model to address interdependent decisions
on vaccine development, global financing, and country adoption
- Performed analyses to determine AMC size and price for six vaccines
in support of the G8 pilot AMC decision-making process
- Educated donors, GH organizations, and suppliers on AMC analysis
methodologies, inputs, and results
- Participated in pilot AMC supplier consultations
- Achieved buy-in from diverse stakeholders
Results
- Consistent and transparent analyses across six vaccines, enabling the G8 to decide on a pilot AMC on merit
- $1.5 billion raised for the first pilot AMC for pneumococcal vaccines
- Expected to accelerate developing-world pneumococcal vaccine introduction by up to 50%
- Anticipate approximately 300,000 children per year will be saved, or a total of 5 million lives by 2030
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